PopED computes optimal experimental designs for both population and individual studies based on nonlinear mixed-effect models. Often this is based on a computation of the Fisher Information Matrix (FIM).
You need to have R installed. Download the latest version of R from www.r-project.org. You can install the released version of PopED from CRAN with:
And the development version from GitHub with:
To get started you need to define
Learn more in this introduction to PopED