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Function takes a design with potentially empty design variables and rescues the design so that a FIM can be calculated using mftot.

Usage

downsizing_general_design(poped.db)

Arguments

poped.db

A PopED database

Value

A list containing:

ni

A vector of the number of samples in each group.

xt

A matrix of sample times. Each row is a vector of sample times for a group.

model_switch

A matrix that is the same size as xt, specifying which model each sample belongs to.

x

A matrix for the discrete design variables. Each row is a group.

a

A matrix of covariates. Each row is a group.

bpop

A matrix of fixed effect parameter values.