Compute the FIM for one individual given specific model(s), parameters, design and methods.
mf3(model_switch, xt, x, a, bpop, d, sigma, docc, poped.db)
model_switch | A vector that is the same size as xt, specifying which model each sample belongs to. |
---|---|
xt | A vector of sample times. |
x | A vector for the discrete design variables. |
a | A vector of covariates. |
bpop | The fixed effects parameter values. Supplied as a vector. |
d | A between subject variability matrix (OMEGA in NONMEM). |
sigma | A residual unexplained variability matrix (SIGMA in NONMEM). |
docc | A between occasion variability matrix. |
poped.db | A PopED database. |
As a list:
The FIM for one individual
A PopED database
Other FIM:
LinMatrixH()
,
LinMatrixLH()
,
LinMatrixL_occ()
,
calc_ofv_and_fim()
,
ed_laplace_ofv()
,
ed_mftot()
,
efficiency()
,
evaluate.e.ofv.fim()
,
evaluate.fim()
,
gradf_eps()
,
mf7()
,
mftot()
,
ofv_criterion()
,
ofv_fim()