Compute the FIM for one individual given specific model(s), parameters, design and methods.
mf3(model_switch, xt, x, a, bpop, d, sigma, docc, poped.db)
| model_switch | A vector that is the same size as xt, specifying which model each sample belongs to. |
|---|---|
| xt | A vector of sample times. |
| x | A vector for the discrete design variables. |
| a | A vector of covariates. |
| bpop | The fixed effects parameter values. Supplied as a vector. |
| d | A between subject variability matrix (OMEGA in NONMEM). |
| sigma | A residual unexplained variability matrix (SIGMA in NONMEM). |
| docc | A between occasion variability matrix. |
| poped.db | A PopED database. |
As a list:
The FIM for one individual
A PopED database
Other FIM:
LinMatrixH(),
LinMatrixLH(),
LinMatrixL_occ(),
calc_ofv_and_fim(),
ed_laplace_ofv(),
ed_mftot(),
efficiency(),
evaluate.e.ofv.fim(),
evaluate.fim(),
gradf_eps(),
mf7(),
mftot(),
ofv_criterion(),
ofv_fim()