This is a structural model function that encodes a model that is one-compartment, oral absorption, single bolus dose, parameterized using KE. The function is suitable for input to the create.poped.database function using the ff_file argument.

ff.PK.1.comp.oral.sd.KE(model_switch, xt, parameters, poped.db)

Arguments

model_switch

a vector of values, the same size as xt, identifying which model response should be computed for the corresponding xt value. Used for multiple response models.

xt

a vector of independent variable values (often time).

parameters

A named list of parameter values.

poped.db

a poped database. This can be used to extract information that may be needed in the model file.

Value

A list consisting of:

  1. y the values of the model at the specified points.

  2. poped.db A (potentially modified) poped database.

See also

Examples

library(PopED) ## find the parameters that are needed to define from the structural model ff.PK.1.comp.oral.sd.KE
#> function (model_switch, xt, parameters, poped.db) #> { #> with(as.list(parameters), { #> y = xt #> y = (DOSE * Favail * KA/(V * (KA - KE))) * (exp(-KE * #> xt) - exp(-KA * xt)) #> return(list(y = y, poped.db = poped.db)) #> }) #> } #> <bytecode: 0x7fe24aba5148> #> <environment: namespace:PopED>
## -- parameter definition function ## -- names match parameters in function ff sfg <- function(x,a,bpop,b,bocc){ parameters=c(KE=bpop[1]*exp(b[1]), V=bpop[2]*exp(b[2]), KA=bpop[3]*exp(b[3]), Favail=bpop[4], DOSE=a[1]) return(parameters) } ## -- Define initial design and design space poped.db <- create.poped.database(ff_fun=ff.PK.1.comp.oral.sd.KE, fg_fun=sfg, fError_fun=feps.prop, bpop=c(KE=0.15/8, V=8, KA=1.0, Favail=1), notfixed_bpop=c(1,1,1,0), d=c(KE=0.07, V=0.02, KA=0.6), sigma=0.01, groupsize=32, xt=c( 0.5,1,2,6,24,36,72,120), minxt=0, maxxt=120, a=70) ## create plot of model without variability plot_model_prediction(poped.db)
## evaluate initial design FIM <- evaluate.fim(poped.db) FIM
#> [,1] [,2] [,3] [,4] [,5] [,6] #> [1,] 1248651.3457 339.370439 144.758375 0.0000000 0.000000 0.0000000 #> [2,] 339.3704 20.724252 -1.777254 0.0000000 0.000000 0.0000000 #> [3,] 144.7584 -1.777254 51.742071 0.0000000 0.000000 0.0000000 #> [4,] 0.0000 0.000000 0.000000 3010.9773834 40.490260 0.1151092 #> [5,] 0.0000 0.000000 0.000000 40.4902598 27487.656006 3.1586320 #> [6,] 0.0000 0.000000 0.000000 0.1151092 3.158632 41.8319046 #> [7,] 0.0000 0.000000 0.000000 784.2206816 10869.344969 70.0662365 #> [,7] #> [1,] 0.00000 #> [2,] 0.00000 #> [3,] 0.00000 #> [4,] 784.22068 #> [5,] 10869.34497 #> [6,] 70.06624 #> [7,] 807063.71904
det(FIM)
#> [1] 3.690649e+24
get_rse(FIM,poped.db)
#> KE V KA d_KE d_V d_KA SIGMA[1,1] #> 4.784638 2.756206 13.925829 26.037875 30.238758 25.770773 11.163214